Using the FISH method for an identification of genetic alterations in cervical carcinoma ane cervical intraepithelial neoplasia: gain of human telomerase gene (hTERC)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00044840" target="_blank" >RIV/00216224:14310/10:00044840 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Using the FISH method for an identification of genetic alterations in cervical carcinoma ane cervical intraepithelial neoplasia: gain of human telomerase gene (hTERC)
Original language description
Cervical cancer is the second most common cancer in women in the Czech Republic, approximately 400 women die of this disease every year. It is known that this carcinoma develops from precancerous cervical intraepithelial neoplasia (CIN) which is characterized by series of genetic abnormalities. Gain of hTERC (3q26) was the most consistent chromosomal abnormality found in cervical carcinoma. It was discovered that gain of hTERC gene is associated with progression from precansers (CIN1, CIN2, CIN3) to cervical carcinoma. In our work, we studied copy number changes of the chromosomal region of hTERC gene using the FISH method in cytological smears obtained from 30 patients of the Departement of Gynaecological Oncology of Masaryk Memorial Cancer InstituteBrno. Gain of hTERC gene was found in 16 from 30 (53 %) patiens with the diagnosis of cervical cancer or with CIN1-CIN3. It was confirmed that gain of hTERC is significantly associated with cervical carcinoma.
Czech name
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Czech description
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Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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