Structure, diversity and evolutionary patterns of expressed MHC class IIB genes in chub (Squalius cephalus), a cyprinid fish species from Europe

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00049665" target="_blank" >RIV/00216224:14310/11:00049665 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00251-010-0495-3" target="_blank" >http://dx.doi.org/10.1007/s00251-010-0495-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00251-010-0495-3" target="_blank" >10.1007/s00251-010-0495-3</a>

Result language

angličtina

Original language name

Structure, diversity and evolutionary patterns of expressed MHC class IIB genes in chub (Squalius cephalus), a cyprinid fish species from Europe

Original language description

The polymorphism of exon 2 of the DAB genes (MHC class IIB) was investigated in the freshwater cyprinid fish species, Squalius cephalus in the wide range of its distribution in Europe. We identified 111 different DAB variants in 15 chub populations. Thesequence analysis showed that many structurally important amino acid sites that were conserved among tetrapods were also conserved in chub. The analysis of recombination indicated that it does not play an important role in producing and maintaining the variation of DAB genes analyzed in the present study. The exon 2 was shown to be subjected to intense positive selection. Phylogenetic analysis and sequence identities suggest the presence of two class IIB loci in chub. A contrasting selection pattern wasfound in DAB1-like and DAB3-like genes, which suggests the potential functional differences between these genes.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Immunogenetics

ISSN

0093-7711

e-ISSN

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Volume of the periodical

63

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

15

Pages from-to

167-181

UT code for WoS article

000287148700004

EID of the result in the Scopus database

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