Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P(2) to LRP6 phosphorylation.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00049716" target="_blank" >RIV/00216224:14310/11:00049716 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1038/emboj.2011.28" target="_blank" >http://dx.doi.org/10.1038/emboj.2011.28</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/emboj.2011.28" target="_blank" >10.1038/emboj.2011.28</a>

Result language

angličtina

Original language name

Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P(2) to LRP6 phosphorylation.

Original language description

Phosphorylation of the Wnt receptor low-density lipoprotein receptor-related protein 6 (LRP6) by glycogen synthase kinase 3beta (GSK3 beta) and casein kinase 1 gama (CK1 gama) is a key step in Wnt/beta-catenin signalling, which requires Wnt-induced formation of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)). Here, we show that adenomatous polyposis coli membrane recruitment 1 (Amer1) (also called WTX), a membrane associated PtdIns(4,5)P(2)-binding protein, is essential for the activation of Wntsignalling at the LRP6 receptor level. Knockdown of Amer1 reduces Wnt-induced LRP6 phosphorylation, Axin translocation to the plasma membrane and formation of LRP6 signalosomes. Overexpression of Amer1 promotes LRP6 phosphorylation, which requires interaction of Amer1 with PtdIns(4,5)P(2). Amer1 translocates to the plasma membrane in a PtdIns(4,5)P(2)-dependent manner after Wnt treatment and is required for LRP6 phosphorylation stimulated by application of PtdIns(4,5)P(2).

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

—

Project

<a href="/en/project/GA204%2F09%2F0498" target="_blank" >GA204/09/0498: Dynamics of proteins interacting with Dishevelled and their importance for Wnt signalling</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

The EMBO journal

ISSN

0261-4189

e-ISSN

—

Volume of the periodical

30

Issue of the periodical within the volume

8

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

1433-1443

UT code for WoS article

000290306300006

EID of the result in the Scopus database

—