All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Structural and Functional Characterization of the Wnt Inhibitor APC Membrane Recruitment 1 (Amer1)

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00054246" target="_blank" >RIV/00216224:14310/11:00054246 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1074/jbc.M111.224881" target="_blank" >http://dx.doi.org/10.1074/jbc.M111.224881</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1074/jbc.M111.224881" target="_blank" >10.1074/jbc.M111.224881</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Structural and Functional Characterization of the Wnt Inhibitor APC Membrane Recruitment 1 (Amer1)

  • Original language description

    Amer1/WTX binds to the tumor suppressor adenomatous polyposis coli and acts as an inhibitor of Wnt signaling by inducing beta catenin degradation. We show here that Amer1 directly interacts with the armadillo repeats of beta catenin via a domain consisting of repeated arginine-glutamic acid-alanine (REA) motifs, and that Amer1 assembles the beta catenin destruction complex at the plasma membrane by recruiting beta catenin, adenomatous polyposis coli, and Axin/Conductin. Deletion or specific mutations ofthe membrane binding domain of Amer1 abolish its membrane localization and abrogate negative control of Wnt signaling, which can be restored by artificial targeting of Amer1 to the plasma membrane. In line, a natural splice variant of Amer1 lacking theplasma membrane localization domain is deficient for Wnt inhibition. Knockdown of Amer1 leads to the activation of Wnt target genes, preferentially in dense compared with sparse cell cultures, suggesting that Amer1 function is regulated b

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    JOURNAL OF BIOLOGICAL CHEMISTRY

  • ISSN

    0021-9258

  • e-ISSN

  • Volume of the periodical

    286

  • Issue of the periodical within the volume

    22

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    19204-19214

  • UT code for WoS article

    000291027700003

  • EID of the result in the Scopus database