Antibacterial agents in innate immunity: comparison of vertebrates and invertebrates

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00049851" target="_blank" >RIV/00216224:14310/11:00049851 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Antibacterial agents in innate immunity: comparison of vertebrates and invertebrates

Original language description

Innate immunity of both vertebrates and invertebrates contents number of antibacterial mechanisms. In invertebrates there is lysozyme and several different antibacterial peptides which are divided according to their stucture to four main groups called linear a-helical, cysteine-stabilized, proline-rich and glycine-rich inducible antimicrobial peptides. In vertebrates antibacterial components cooperate with antibodies, complement cascade and myeloperoxidase activity. Nowadays, many common methods for determination of non-specific innate immune parameters are known in vertebrates, nevertheless there is not so large variety of them in invertebrates. Therefore we tried to apply to invertebrates the bioluminescent bacteria-based assay which is commonly usedfor complement determination in vertebrates. Bioluminescent bacteria are frequent in salt water environment, but there is the only one genus of soil bacteria with natural bioluminescence ? Photorhabdus sp.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/GP206%2F09%2FP470" target="_blank" >GP206/09/P470: The influence of the eicosanoid biosynthesis inhibitors to immunity of the wax moth Galleria mellonella</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů