The invertebrate immune system as a model for investigating the environmental impact of nanoparticles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00425739" target="_blank" >RIV/61388971:_____/13:00425739 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The invertebrate immune system as a model for investigating the environmental impact of nanoparticles
Original language description
Invertebrates lack an adaptive immunity; however, they are endowed with a potent and complex innate immune system similar to that of vertebrates. In most invertebrates, free circulating cells (hemocytes) are responsible for cell-mediated immunity; when activated, different hemocyte types are capable of phagocytosis, reactive oxygen species and NO production, release of hydrolytic enzymes and antimicrobial peptides. Conservation of the general mechanisms of innate immunity from invertebrates to mammals is useful for the evaluation of the environmental impact of nanoparticles. The mechanisms of innate immunity in two model representatives of aquatic (bivalves) and terrestrial (earthworms) environments are summarized, and data supporting the view that cell-mediated immunity can represent the primary target of nanoparticles in invertebrates are presented. The evaluation of immune parameters in invertebrate models may represent a powerful tool for the rapid screening of the immunomodulatory
Czech name
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Czech description
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Project
<a href="/en/project/EE2.3.20.0055" target="_blank" >EE2.3.20.0055: Establishment of teams for The center of microbiology and immunology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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