Nematode infections are affected by insect clotting system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00049861" target="_blank" >RIV/00216224:14310/11:00049861 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Nematode infections are affected by insect clotting system
Original language description
Entomopathogenic nematodes (EPN?s) of the genera Heterorhabditis are obligate and lethal insect parasites. In recent years they have been used increasingly as biological control agents. Infective juveniles occur free living in the soil and are capable ofseeking out hosts and penetrate them through the cuticle or natural orifices. EPN?s are symbiotically associated with bacteria of the genera Photorhabdus. The bacterial symbionts are essential to kill the host (within 24-48 hours) and digest host tissues. Drosophila larvae are more resistant to nematode infection than Galleria mellonella, but both can be used as natural infection model. The tripartite model (Drosophila, nematodes, bacteria) was recently established and used to show an immune function for transglutaminase, a conserved clotting factor. In this study we used different Drosophila mutants or RNAi lines with defects in clotting or other branches of the immune system.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP206%2F09%2FP470" target="_blank" >GP206/09/P470: The influence of the eicosanoid biosynthesis inhibitors to immunity of the wax moth Galleria mellonella</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů