Post-translational modifications regulate signalling by Ror1
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00050218" target="_blank" >RIV/00216224:14310/11:00050218 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/11:00440915
Result on the web
<a href="http://dx.doi.org/10.1111/j.1748-1716.2011.02306.x" target="_blank" >http://dx.doi.org/10.1111/j.1748-1716.2011.02306.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1748-1716.2011.02306.x" target="_blank" >10.1111/j.1748-1716.2011.02306.x</a>
Alternative languages
Result language
angličtina
Original language name
Post-translational modifications regulate signalling by Ror1
Original language description
Ror1 (receptor tyrosine kinase-like orphan receptor)is highly upregulated in B cells of patients with chronic lymphocytic leukaemia (CLL). Ror1 acts as the Wnt receptor in the non-canonical Wnt pathway. We demonstrate that Ror1 is extensively modified byN-linked glycosylation. Glycosylation produces several variants of Ror1 with electrophoretic migration of approx. 100, 115 and 130 kDa. Inhibition of glycosylation interferes with cell surface localization of the 130-kDa variant of Ror1 and prevents Ror1-induced formation of filopodia. Moreover, we show that 130-kDa Ror1 is mono-ubiquitinated. Furthermore, individual CLL patients show striking differences in the electrophoretic migration of Ror1, which correspond to the level of glycosylation. Our datashow that Ror1 undergoes complex post-translational modifications by glycosylation and mono-ubiquitination. These modifications regulate Ror1 localization and signalling, and are highly variable among individual CLL patients.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Physiologica
ISSN
1748-1708
e-ISSN
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Volume of the periodical
203
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
351-362
UT code for WoS article
000296061800002
EID of the result in the Scopus database
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