Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00569246" target="_blank" >RIV/68081707:_____/22:00569246 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/22:00076170 RIV/00216224:14310/22:00125590 RIV/65269705:_____/22:00076170
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fcell.2022.838871/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcell.2022.838871/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcell.2022.838871" target="_blank" >10.3389/fcell.2022.838871</a>
Alternative languages
Result language
angličtina
Original language name
Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells
Original language description
Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of ROR1, the cell surface receptor for Wnt-5a. Both, BCR and ROR1 are therapeutic targets in these diseases and the understanding of their mutual cross talk is thus of direct therapeutic relevance. In this study we analyzed the role of Lyn, a kinase from the Src family participating in BCR signaling, as a mediator of the BCR-ROR1 crosstalk. We confirm the functional interaction between Lyn and ROR1 and demonstrate that Lyn kinase efficiently phosphorylates ROR1 in its kinase domain and aids the recruitment of the E3 ligase c-CBL. We show that ROR1 surface dynamics in migrating primary CLL cells as well as chemotactic properties of CLL cells were inhibited by Lyn inhibitor dasatinib. Our data establish Lyn-mediated phosphorylation of ROR1 as a point of crosstalk between BCR and ROR1 signaling pathways.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cell and Developmental Biology
ISSN
2296-634X
e-ISSN
2296-634X
Volume of the periodical
9
Issue of the periodical within the volume
FEB 28 2022
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
838871
UT code for WoS article
000896044000001
EID of the result in the Scopus database
2-s2.0-85126728312