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Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00569246" target="_blank" >RIV/68081707:_____/22:00569246 - isvavai.cz</a>

  • Alternative codes found

    RIV/00159816:_____/22:00076170 RIV/00216224:14310/22:00125590 RIV/65269705:_____/22:00076170

  • Result on the web

    <a href="https://www.frontiersin.org/articles/10.3389/fcell.2022.838871/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcell.2022.838871/full</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3389/fcell.2022.838871" target="_blank" >10.3389/fcell.2022.838871</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells

  • Original language description

    Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of ROR1, the cell surface receptor for Wnt-5a. Both, BCR and ROR1 are therapeutic targets in these diseases and the understanding of their mutual cross talk is thus of direct therapeutic relevance. In this study we analyzed the role of Lyn, a kinase from the Src family participating in BCR signaling, as a mediator of the BCR-ROR1 crosstalk. We confirm the functional interaction between Lyn and ROR1 and demonstrate that Lyn kinase efficiently phosphorylates ROR1 in its kinase domain and aids the recruitment of the E3 ligase c-CBL. We show that ROR1 surface dynamics in migrating primary CLL cells as well as chemotactic properties of CLL cells were inhibited by Lyn inhibitor dasatinib. Our data establish Lyn-mediated phosphorylation of ROR1 as a point of crosstalk between BCR and ROR1 signaling pathways.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Frontiers in Cell and Developmental Biology

  • ISSN

    2296-634X

  • e-ISSN

    2296-634X

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    FEB 28 2022

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    11

  • Pages from-to

    838871

  • UT code for WoS article

    000896044000001

  • EID of the result in the Scopus database

    2-s2.0-85126728312