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WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F17%3A00095705" target="_blank" >RIV/00216224:14310/17:00095705 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1111/bph.13949" target="_blank" >http://dx.doi.org/10.1111/bph.13949</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/bph.13949" target="_blank" >10.1111/bph.13949</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas

  • Original language description

    In this review, we discuss the intricate roles of the Wnt signalling network in the development and progression of mature B-cell-derived haematological malignancies, with a focus on chronic lymphocytic leukaemia (CLL) and related B-cell lymphomas. We review the current literature and highlight the differences between the beta-catenin-dependent and -independent branches of Wnt signalling. Special attention is paid to the role of the non-canonical Wnt/planar cell polarity (PCP) pathway, mediated by the Wnt-5-receptor tyrosine kinase-like orphan receptor (ROR1)-Dishevelled signalling axis in CLL. This is mainly because the Wnt/PCP co-receptor ROR1 was found to be overexpressed in CLL and the Wnt/PCP pathway contributes to numerous aspects of CLL pathogenesis. We also discuss the possibilities of therapeutically targeting the Wnt signalling pathways as an approach to disrupt the crucial interaction between malignant cells and their micro-environment. We also advocate the need for research in this direction for other lymphomas, namely, diffuse large B-cell lymphoma, Hodgkin lymphoma, mantle cell lymphoma, Burkitt lymphoma and follicular lymphoma where the Wnt signalling pathway probably plays a similar role.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30205 - Hematology

Result continuities

  • Project

    <a href="/en/project/NV15-29793A" target="_blank" >NV15-29793A: Analysis of WNT/PCP pathway for better management of chronic lymphocytic leukemia</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    BRITISH JOURNAL OF PHARMACOLOGY

  • ISSN

    0007-1188

  • e-ISSN

  • Volume of the periodical

    174

  • Issue of the periodical within the volume

    24

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    15

  • Pages from-to

    4701-4715

  • UT code for WoS article

    000427839000012

  • EID of the result in the Scopus database