WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F17%3A00095705" target="_blank" >RIV/00216224:14310/17:00095705 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/bph.13949" target="_blank" >http://dx.doi.org/10.1111/bph.13949</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bph.13949" target="_blank" >10.1111/bph.13949</a>
Alternative languages
Result language
angličtina
Original language name
WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas
Original language description
In this review, we discuss the intricate roles of the Wnt signalling network in the development and progression of mature B-cell-derived haematological malignancies, with a focus on chronic lymphocytic leukaemia (CLL) and related B-cell lymphomas. We review the current literature and highlight the differences between the beta-catenin-dependent and -independent branches of Wnt signalling. Special attention is paid to the role of the non-canonical Wnt/planar cell polarity (PCP) pathway, mediated by the Wnt-5-receptor tyrosine kinase-like orphan receptor (ROR1)-Dishevelled signalling axis in CLL. This is mainly because the Wnt/PCP co-receptor ROR1 was found to be overexpressed in CLL and the Wnt/PCP pathway contributes to numerous aspects of CLL pathogenesis. We also discuss the possibilities of therapeutically targeting the Wnt signalling pathways as an approach to disrupt the crucial interaction between malignant cells and their micro-environment. We also advocate the need for research in this direction for other lymphomas, namely, diffuse large B-cell lymphoma, Hodgkin lymphoma, mantle cell lymphoma, Burkitt lymphoma and follicular lymphoma where the Wnt signalling pathway probably plays a similar role.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/NV15-29793A" target="_blank" >NV15-29793A: Analysis of WNT/PCP pathway for better management of chronic lymphocytic leukemia</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BRITISH JOURNAL OF PHARMACOLOGY
ISSN
0007-1188
e-ISSN
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Volume of the periodical
174
Issue of the periodical within the volume
24
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
4701-4715
UT code for WoS article
000427839000012
EID of the result in the Scopus database
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