Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00051960" target="_blank" >RIV/00216224:14310/11:00051960 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/11:00440859

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells

Original language description

BACKGROUND: Shb, a ubiquitously expressed Src homology 2 domain-containing adaptor protein has previously been implicated in the signaling of various tyrosine kinase receptors including the TCR. Shb associates with SLP76, LAT and Vav, all important components in the signaling cascade governing T cell function and development. A Shb knockout mouse was recently generated and the aim of the current study was to address the importance of Shb deficiency on T cell development and function. RESULTS: Shb knockout mice did not display any major changes in thymocyte development despite an aberrant TCR signaling pattern, including increased basal activation and reduced stimulation-induced phosphorylation. The loss of Shb expression did however affect peripheral CD4+ T(H) cells resulting in an increased proliferative response to TCR stimulation and an elevated IL-4 production of naive T(H) cells. This suggests a T(H)2 skewing of the Shb knockout immune system, seemingly caused by an altered TCR si

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC immunology

ISSN

1471-2172

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

3

Country of publishing house

SE - SWEDEN

Number of pages

10

Pages from-to

1-10

UT code for WoS article

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EID of the result in the Scopus database

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