Electrochemical DNA Sensors Based on Adsorptive and Elimination Techniques

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00052406" target="_blank" >RIV/00216224:14310/11:00052406 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Electrochemical DNA Sensors Based on Adsorptive and Elimination Techniques
Original language description
Electrochemistry-based sensors offer good sensitivity, separation ability, low cost for the detection of ODNs and selected DNA sequences or of muteted genes associated with diseases. Numerous developed approaches, such as the platforms or direct or indirect electrochemistry DNA, specific redox indicator, or mediated charge transport, can be improved by the adsorptive stripping technique in connection with elimination voltammetry with linear scan (AdS EVLS). Here we verify our idea on the electrode systems of homo-and hetero-oligodeoxynuleotides (ODNs) including hairpins. The EVLS was applied to the resolution of reduction signals of adenine (A) and cytosine (C) in short synthetic ODNs. The Ads EVLS results showed that the elimination functions chosen are also useful for the study not only of cathodic but also of anodic processes, especially for the anodic processes of guanine. Due to AdS EVLS or AdTS EVLS we are able to evaluate the ODN structure changes on electrode surfaces.
Czech name
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Czech description
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Project
<a href="/en/project/LC06035" target="_blank" >LC06035: Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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