c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00057318" target="_blank" >RIV/00216224:14310/12:00057318 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/12:00389677 RIV/00159816:_____/12:#0000934
Result on the web
<a href="http://dx.doi.org/10.1186/1476-4598-11-15" target="_blank" >http://dx.doi.org/10.1186/1476-4598-11-15</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1476-4598-11-15" target="_blank" >10.1186/1476-4598-11-15</a>
Alternative languages
Result language
angličtina
Original language name
c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis
Original language description
The aim of this study was to investigate the role of c-Myb in the metastatic spread of breast tumors. We ectopically expressed c-Myb in human MDA-MB-231 and mouse 4T1 mammary cancer cells to find that c-Myb enhanced migration and ability of these cells to invade Matrigel but not the collagen I matrix in vitro. c-Myb strongly increased the expression/activity of cathepsin D and matrix metalloproteinase (MMP) 9 and significantly downregulated MMP1. The gene coding for cathepsin D was found to act as the c-Myb-responsive gene and downstream effector of the migration-promoting function of c-Myb. Finally, we demonstrated that c-Myb delayed the growth of mammary tumors in BALB/c mice and affected the metastatic potential of breast cancer cells in an organ-specific manner. This study identified c-Myb as a matrix-dependent regulator of invasive behavior of breast cancer cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Cancer
ISSN
1476-4598
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
MARCH
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
15-29
UT code for WoS article
000302805400001
EID of the result in the Scopus database
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