Application of On-line Capillary Electrophoresis Coupled to Mass Spectrometry for Identification of Cytochrome P450 2C9 Isoform Metabolism Products
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00057805" target="_blank" >RIV/00216224:14310/12:00057805 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Application of On-line Capillary Electrophoresis Coupled to Mass Spectrometry for Identification of Cytochrome P450 2C9 Isoform Metabolism Products
Original language description
Drug biotransformation mediated by cytochrome P450 enzymes (CYP) is a pivotal factor in the early developmental stages of new drugs. Metabolism appraisal of every hit thus constitutes the inseparable part of ADME/tox screenings. Capillary electrophoresis(CE) represents a promising technique in the field of enzyme assays due to miniscule sample consumption and high-throughput by automation. Moreover, CE coupled to mass spectrometry (MS) combines the advantages of both techniques so that CYP metabolism products can be identified on the bases of migration time, molecular weight and fragmentation. A new CE-MS method enabling identification of reaction products provided by clinically important CYP2C9 isoform is thus introduced.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
9th International Interdisciplinary Meeting on Bioanalysis, CECE 2012
ISBN
9788090495913
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
368-371
Publisher name
IACH AV ČR Brno
Place of publication
Brno
Event location
Brno
Event date
Nov 1, 2012
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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