Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00060467" target="_blank" >RIV/00216224:14310/12:00060467 - isvavai.cz</a>

Alternative codes found

RIV/00209775:_____/12:#0000239 RIV/65269705:_____/12:#0001979

Result on the web

<a href="http://dx.doi.org/10.3892/ijo.2012.1520" target="_blank" >http://dx.doi.org/10.3892/ijo.2012.1520</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/ijo.2012.1520" target="_blank" >10.3892/ijo.2012.1520</a>

Result language

angličtina

Original language name

Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells

Original language description

The p53 protein is a sequence-specific transcription factor controlling the expression of multiple genes and protecting cells from oncogenic transformation. In many tumors, the p53 protein is completely or partially inactivated by mutations in the p53 gene. We analyzed the transactivating activity of nine human temperature-dependent (td) p53 mutants in yeast cells. Mutations in seven of them were localized in the beta-sandwich-coding region of the p53 gene, eight p53 mutants were temperature-sensitive and the R283C mutant was coldsensitive. Patterns of their transactivation abilities towards three different responsive elements, the extent of their temperature dependency as well as discriminativity, were considerably variable. Similarly, their capacityto become reactivated by amifostine varied from complete resistance to high sensitivity.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NS10448" target="_blank" >NS10448: Detailed analyses of temperature-dependent mutants of the p53 tumor suppressor in human cells</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Oncology

ISSN

1019-6439

e-ISSN

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Volume of the periodical

41

Issue of the periodical within the volume

3

Country of publishing house

GR - GREECE

Number of pages

7

Pages from-to

1157-1163

UT code for WoS article

000307150000042

EID of the result in the Scopus database

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