Multidrug resistance-associated ABC transporters ? too much of one thing, good for nothing

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00063603" target="_blank" >RIV/00216224:14310/12:00063603 - isvavai.cz</a>
Result on the web
<a href="http://www.degruyter.com/view/j/bmc" target="_blank" >http://www.degruyter.com/view/j/bmc</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/bmc-2012-0006" target="_blank" >10.1515/bmc-2012-0006</a>

Result language
angličtina
Original language name
Multidrug resistance-associated ABC transporters ? too much of one thing, good for nothing
Original language description
Overexpression of ATP-binding cassette (ABC) transporters in cancer cells results in multidrug resistance (MDR) which leads to unsuccessful chemotherapy. The most important MDR-associated members of ABC superfamily are ABC B1/P-glycoprotein/MDR1, ABC C1/multidrug resistance associated protein 1 (MRP1), and ABC G2/BCRP. This study is not only focused on function, substrates, and localization of these popular proteins but also on other ABC C family members such as ABC C2?6/MRP2-6 and ABC C7/CFTR. Currentresearch is mainly oriented on the cancer-promoting role of these proteins, but important lessons could also be learned from the physiological roles of these proteins or from polymorphisms affecting their function. Thorough knowledge of structure and detailed mechanism of efflux can aid in the discovery of new chemotherapy targets in the future.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)