Defying Multidrug Resistance! Modulation of Related Transporters by Flavonoids and Flavonolignans

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F20%3A43921268" target="_blank" >RIV/60461373:22330/20:43921268 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/20:00524416
Result on the web
<a href="https://pubs.acs.org/doi/abs/10.1021/acs.jafc.9b00694" target="_blank" >https://pubs.acs.org/doi/abs/10.1021/acs.jafc.9b00694</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.jafc.9b00694" target="_blank" >10.1021/acs.jafc.9b00694</a>

Result language
angličtina
Original language name
Defying Multidrug Resistance! Modulation of Related Transporters by Flavonoids and Flavonolignans
Original language description
Multidrug resistance (MDR) is a major challenge for the 21th century in both cancer chemotherapy and antibiotic treatment of bacterial infections. Efflux pumps and transport proteins play an important role in MDR. Compounds displaying inhibitory activity toward these proteins are prospective for adjuvant treatment of such conditions. Natural low-cost and nontoxic flavonoids, thanks to their vast structural diversity, offer a great pool of lead structures with broad possibility of chemical derivatizations. Various flavonoids were found to reverse both antineoplastic and bacterial multidrug resistance by inhibiting Adenosine triphosphate Binding Cassette (ABC)-transporters (human P-glycoprotein, multidrug resistance-associated protein MRP-1, breast cancer resistance protein, and bacterial ABC transporters), as well as other bacterial drug efflux pumps: major facilitator superfamily (MFS), multidrug and toxic compound extrusion (MATE), small multidrug resistance (SMR) and resistance-nodulation-cell-division (RND) transporters, and glucose transporters. Flavonoids and particularly flavonolignans are therefore highly prospective compounds for defying multidrug resistance.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)