Thiazolidinediones Regulate the Level of ABC Transporters Expression on Lung Cancer Cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00086936" target="_blank" >RIV/00216224:14310/15:00086936 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.14735/amko2015431" target="_blank" >http://dx.doi.org/10.14735/amko2015431</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14735/amko2015431" target="_blank" >10.14735/amko2015431</a>

Result language
angličtina
Original language name
Thiazolidinediones Regulate the Level of ABC Transporters Expression on Lung Cancer Cells
Original language description
ATP binding cassette (ABC) transporters related to multidrug resistance (MDR) actively efflux various xenobiotics from the cells across the cell membrane and decrease a drugs efficiency. Lung cancer is the leading cause of death among all types of cancerin the Czech Republic, and its incidence is still rising. Ciglitazone, rosiglitazone and troglitazone belonging to PPARgama agonist family (formerly used in diabetes mellitus treatment) were selected to investigate their capability to influence expression of ABC transporters on lung cancer cells. Therefore, the effect of PPARgama of agonists on transcription of following ABC transporters was investigated: multidrug resistance protein 1 (MDR1), multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein (BCRP). We have investigated if these PPARgama agonists are substrates of ABC transporters using HL60 and HL60 derived cell lines (HL60-MDR1, HL60-MRP1, PLB-BCRP) by cytotoxicity test WST-1.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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