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Thiazolidinediones Regulate the Level of ABC Transporters Expression on Lung Cancer Cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00086936" target="_blank" >RIV/00216224:14310/15:00086936 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.14735/amko2015431" target="_blank" >http://dx.doi.org/10.14735/amko2015431</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.14735/amko2015431" target="_blank" >10.14735/amko2015431</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Thiazolidinediones Regulate the Level of ABC Transporters Expression on Lung Cancer Cells

  • Original language description

    ATP binding cassette (ABC) transporters related to multidrug resistance (MDR) actively efflux various xenobiotics from the cells across the cell membrane and decrease a drugs efficiency. Lung cancer is the leading cause of death among all types of cancerin the Czech Republic, and its incidence is still rising. Ciglitazone, rosiglitazone and troglitazone belonging to PPARgama agonist family (formerly used in diabetes mellitus treatment) were selected to investigate their capability to influence expression of ABC transporters on lung cancer cells. Therefore, the effect of PPARgama of agonists on transcription of following ABC transporters was investigated: multidrug resistance protein 1 (MDR1), multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein (BCRP). We have investigated if these PPARgama agonists are substrates of ABC transporters using HL60 and HL60 derived cell lines (HL60-MDR1, HL60-MRP1, PLB-BCRP) by cytotoxicity test WST-1.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Klinicka onkologie Journal

  • ISSN

    0862-495X

  • e-ISSN

  • Volume of the periodical

    28

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    8

  • Pages from-to

    431-438

  • UT code for WoS article

  • EID of the result in the Scopus database