Pro- and anti-tumor effects of wedelolactone in breast cancer cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00065616" target="_blank" >RIV/00216224:14310/13:00065616 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Pro- and anti-tumor effects of wedelolactone in breast cancer cells
Original language description
Natural phytocompounds and their derivatives are commonly used for prevention and treatment of various diseases, including cancer. Wedelolactone is one of the active polyphenolic compounds in extracts of Wedelia calandulaceae and Eclipta prostrata. Wedelolactone was shown to inhibit growth of breast and prostate cancer cells in vitro and in vivo. The growth inhibitory effects of wedelolactone have been largely attributed to the inhibition of IKK kinase, the key enzyme regulating the activity of NFkB. Wehave recently described that wedelolactone inhibits DNA synthesis and acts as catalytic inhibitor of DNA topoisomerase IIalpha. This study was designed to characterize the mechanisms of wedelolactone effects on breast cancer cells in detail. We observedthat in nM concentrations, wedelolactone stimulates growth of ER-positive breast cancer cells MCF-7 and T47D by activation of genomic ER-signalling pathway. This growth-stimulatory effect was not detected in ER-negative MDA-MB-231 breast
Czech name
—
Czech description
—

Project
<a href="/en/project/NT13441" target="_blank" >NT13441: Myb Protein Family Expression in Colorectal Adenocarcinoma and its Correlation to Metastatic Potential</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)