EGFR signaling in the HGG-02 glioblastoma cell line with an unusual loss of EGFR gene copy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00074892" target="_blank" >RIV/00216224:14310/14:00074892 - isvavai.cz</a>

Alternative codes found

RIV/00209805:_____/14:#0000498

Result on the web

<a href="http://dx.doi.org/10.3892/or.2013.2864" target="_blank" >http://dx.doi.org/10.3892/or.2013.2864</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/or.2013.2864" target="_blank" >10.3892/or.2013.2864</a>

Result language

angličtina

Original language name

EGFR signaling in the HGG-02 glioblastoma cell line with an unusual loss of EGFR gene copy

Original language description

Epidermal growth factor receptor (EGFR) gene amplification and the overexpression of EGFR are described as common features of glioblastoma multiforme (GBM). Nevertheless, we previously reported the loss of EGFR gene copy in a GBM specimen from a patientwith an unusually favorable course of the disease, and the HGG-02 cell line with this aberration was successfully derived from this tumor. Here, we present a detailed analysis of changes in gene expression and cell signaling in the HGG-02 cell line; theGM7 reference cell line with a standard EGFR gene copy number derived from a very aggressive GBM was used as a control. We confirmed the downregulation of EGFR expression and signaling in HGG-02 cells using different methods (RTK analysis, gene profilingand RT-PCR). Other changes that may have contributed to the non-aggressive phenotype of the primary tumor were identified, including the downregulated phosphorylation of the Axl and Trk receptors, as well as increased activity of JNK and

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncology Reports

ISSN

1021-335X

e-ISSN

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Volume of the periodical

31

Issue of the periodical within the volume

1

Country of publishing house

GR - GREECE

Number of pages

8

Pages from-to

480-487

UT code for WoS article

000330788100065

EID of the result in the Scopus database

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