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Transgelins, cytoskeletal proteins implicated in different aspects of cancer development

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00074976" target="_blank" >RIV/00216224:14310/14:00074976 - isvavai.cz</a>

  • Alternative codes found

    RIV/00209805:_____/14:#0000505

  • Result on the web

    <a href="http://dx.doi.org/10.1586/14789450.2014.860358" target="_blank" >http://dx.doi.org/10.1586/14789450.2014.860358</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1586/14789450.2014.860358" target="_blank" >10.1586/14789450.2014.860358</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Transgelins, cytoskeletal proteins implicated in different aspects of cancer development

  • Original language description

    Transgelin is an abundant protein of smooth muscle cells, where its role has been primarily studied. As a protein affecting dynamics of the actin cytoskeleton via stabilization of actin filaments, transgelin is both directly and indirectly involved in many cancer-related processes such as migration, proliferation, differentiation or apoptosis. Transgelin was previously reviewed as a tumor suppressor; however, recent data based on a number of proteomics studies indicate its pro-tumorigenic role, for example, in colorectal or hepatocellular cancer. We summarize these contradictory observations in both clinical and functional proteomics projects and analyze the role of transgelin in tumors in detail. Generally, the expression and biological role of transgelin seem to differ among various types of tumor cells and stroma, and possibly change during tumor progression.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Expert Review of Proteomics

  • ISSN

    1478-9450

  • e-ISSN

  • Volume of the periodical

    11

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    17

  • Pages from-to

    149-165

  • UT code for WoS article

    000335649300004

  • EID of the result in the Scopus database