Transgelins, cytoskeletal proteins implicated in different aspects of cancer development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00074976" target="_blank" >RIV/00216224:14310/14:00074976 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/14:#0000505
Result on the web
<a href="http://dx.doi.org/10.1586/14789450.2014.860358" target="_blank" >http://dx.doi.org/10.1586/14789450.2014.860358</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1586/14789450.2014.860358" target="_blank" >10.1586/14789450.2014.860358</a>
Alternative languages
Result language
angličtina
Original language name
Transgelins, cytoskeletal proteins implicated in different aspects of cancer development
Original language description
Transgelin is an abundant protein of smooth muscle cells, where its role has been primarily studied. As a protein affecting dynamics of the actin cytoskeleton via stabilization of actin filaments, transgelin is both directly and indirectly involved in many cancer-related processes such as migration, proliferation, differentiation or apoptosis. Transgelin was previously reviewed as a tumor suppressor; however, recent data based on a number of proteomics studies indicate its pro-tumorigenic role, for example, in colorectal or hepatocellular cancer. We summarize these contradictory observations in both clinical and functional proteomics projects and analyze the role of transgelin in tumors in detail. Generally, the expression and biological role of transgelin seem to differ among various types of tumor cells and stroma, and possibly change during tumor progression.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Expert Review of Proteomics
ISSN
1478-9450
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
17
Pages from-to
149-165
UT code for WoS article
000335649300004
EID of the result in the Scopus database
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