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Electrochemical and Spectral Analysis of Cytosine and Guanine Homo-oligodeoxynucleotides

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00075817" target="_blank" >RIV/00216224:14310/14:00075817 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    čeština

  • Original language name

    Electrochemical and Spectral Analysis of Cytosine and Guanine Homo-oligodeoxynucleotides

  • Original language description

    Oligodeoxynucleotides (ODNs) with repetitive cytosine (C) or guanine (G) sequences are observed in the promoter region of the oncogenes and of human telomeric DNA. Here we present electrochemical and spectral studies of short C or G homo-ODNs in solutions with different pH. Electrochemistry was represented by linear sweep or cyclic voltammetry in connection with a hanging mercury drop electrode (HMDE). As a spectral method circular dichroism was used. It was found that cytosine ODNs form stable structures, the so-called i-motifs and guanine ODN structures form tetraplex via a G-quartet. Both structures are dependent on pH and the ODN chain length.

  • Czech name

    Electrochemical and Spectral Analysis of Cytosine and Guanine Homo-oligodeoxynucleotides

  • Czech description

    Oligodeoxynucleotides (ODNs) with repetitive cytosine (C) or guanine (G) sequences are observed in the promoter region of the oncogenes and of human telomeric DNA. Here we present electrochemical and spectral studies of short C or G homo-ODNs in solutions with different pH. Electrochemistry was represented by linear sweep or cyclic voltammetry in connection with a hanging mercury drop electrode (HMDE). As a spectral method circular dichroism was used. It was found that cytosine ODNs form stable structures, the so-called i-motifs and guanine ODN structures form tetraplex via a G-quartet. Both structures are dependent on pH and the ODN chain length.

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    CF - Physical chemistry and theoretical chemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    XXXIV. Moderní Elektrochemické Metody

  • ISBN

    9788090522121

  • ISSN

  • e-ISSN

  • Number of pages

    4

  • Pages from-to

    49-52

  • Publisher name

    Srsenová Lenka - Best servis Ústí nad Labem

  • Place of publication

    Jetřichovice

  • Event location

    Jetřichovice

  • Event date

    Jan 1, 2014

  • Type of event by nationality

    EUR - Evropská akce

  • UT code for WoS article