Electrochemical and Spectral Analysis of Cytosine and Guanine Homo-oligodeoxynucleotides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00075817" target="_blank" >RIV/00216224:14310/14:00075817 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
čeština
Original language name
Electrochemical and Spectral Analysis of Cytosine and Guanine Homo-oligodeoxynucleotides
Original language description
Oligodeoxynucleotides (ODNs) with repetitive cytosine (C) or guanine (G) sequences are observed in the promoter region of the oncogenes and of human telomeric DNA. Here we present electrochemical and spectral studies of short C or G homo-ODNs in solutions with different pH. Electrochemistry was represented by linear sweep or cyclic voltammetry in connection with a hanging mercury drop electrode (HMDE). As a spectral method circular dichroism was used. It was found that cytosine ODNs form stable structures, the so-called i-motifs and guanine ODN structures form tetraplex via a G-quartet. Both structures are dependent on pH and the ODN chain length.
Czech name
Electrochemical and Spectral Analysis of Cytosine and Guanine Homo-oligodeoxynucleotides
Czech description
Oligodeoxynucleotides (ODNs) with repetitive cytosine (C) or guanine (G) sequences are observed in the promoter region of the oncogenes and of human telomeric DNA. Here we present electrochemical and spectral studies of short C or G homo-ODNs in solutions with different pH. Electrochemistry was represented by linear sweep or cyclic voltammetry in connection with a hanging mercury drop electrode (HMDE). As a spectral method circular dichroism was used. It was found that cytosine ODNs form stable structures, the so-called i-motifs and guanine ODN structures form tetraplex via a G-quartet. Both structures are dependent on pH and the ODN chain length.
Classification
Type
D - Article in proceedings
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
XXXIV. Moderní Elektrochemické Metody
ISBN
9788090522121
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
49-52
Publisher name
Srsenová Lenka - Best servis Ústí nad Labem
Place of publication
Jetřichovice
Event location
Jetřichovice
Event date
Jan 1, 2014
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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