PHYSICOCHEMICAL METHODS AS A SUITABLE INSTRUMENT FOR SHORT DNA FRAGMENTS STUDY
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00075780" target="_blank" >RIV/00216224:14310/14:00075780 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
PHYSICOCHEMICAL METHODS AS A SUITABLE INSTRUMENT FOR SHORT DNA FRAGMENTS STUDY
Original language description
Oligodeoxynucleotides (ODNs) are observed in the promoter region of the oncogens and of human telomeric DNA as a multiple repetitive C- or G- sequences. These sequences form tetraplex structures. C- rich ODNs form the so called i-motif, a hemiprotonatedC-C+ base pairing structures, at slightly acidic pH. G- rich ODNs form a G-quartet, made from four guanines and stabilized by a metal kation and can be folded into a G-tetraplex. We used electrochemical methods to study the behaviour of these compounds in buffered solutions with different pH, so we can comparatively evaluate the structure and fiction of each homo-ODN for better understanding their behaviour in solutions and on the charged interface. The study was completed by circular dichroism spektrato confirm the structure. Results should provide better understanding of these compounds, so the suitable biosensor could be designed.
Czech name
—
Czech description
—
Classification
Type
D - Article in proceedings
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Sborník příspěvků XIV. Pracovní setkání fyzikálních chemiků a elektrochemiků
ISBN
9788021068421
ISSN
—
e-ISSN
—
Number of pages
4
Pages from-to
40-43
Publisher name
Masarykova univerzita
Place of publication
Brno
Event location
Brno
Event date
Jan 1, 2014
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
—