Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00077288" target="_blank" >RIV/00216224:14310/14:00077288 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/14:00061297 RIV/00209805:_____/14:#0000568

Result on the web

<a href="http://dx.doi.org/10.2174/1871520614666140713172949" target="_blank" >http://dx.doi.org/10.2174/1871520614666140713172949</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1871520614666140713172949" target="_blank" >10.2174/1871520614666140713172949</a>

Result language

angličtina

Original language name

Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy

Original language description

Natural products are often used in drug development due to their ability to form unique and diverse chemical structures. Coumestans are polycyclic aromatic plant secondary metabolites containing a coumestan moiety, which consists of a benzoxole fused toa chromen-2-one to form 1-Benzoxolo[3,2-c]chromen-6-one. These natural compounds are known for large number of biological activities. Many of their biological effects can be attributed to their action as phytoestrogens and polyphenols. In the last decade, anticancer effects of these compounds have been described in vitro but there is only limited number of studies based on models in vivo. More information concerning their in vivo bioavailability, stability, metabolism, toxicity, estrogenicity, cellulartargets and drug interactions is therefore needed to proceed further to clinical studies. This review focuses on coumestans exhibiting anticancer properties and summarizes mechanisms of their toxicity to cancer cells.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anti-Cancer Agents in Medicinal Chemistry

ISSN

1871-5206

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

10

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

12

Pages from-to

1351-1362

UT code for WoS article

000345226600006

EID of the result in the Scopus database

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