The ATRA-induced differentiation of medulloblastoma cells is enhanced with LOX/COX inhibitors: an analysis of gene expression.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00079004" target="_blank" >RIV/00216224:14310/14:00079004 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/14:#0000554
Result on the web
<a href="http://www.cancerci.com/content/14/1/51" target="_blank" >http://www.cancerci.com/content/14/1/51</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1475-2867-14-51" target="_blank" >10.1186/1475-2867-14-51</a>
Alternative languages
Result language
angličtina
Original language name
The ATRA-induced differentiation of medulloblastoma cells is enhanced with LOX/COX inhibitors: an analysis of gene expression.
Original language description
A detailed analysis of the expression of 440 cancer-related genes was performed after the combined treatment of medulloblastoma cells with all-trans retinoic acid (ATRA) and inhibitors of lipoxygenases (LOX) and cyclooxygenases (COX). The Daoy and D283 Med medulloblastoma cell lines were chosen for this study. Caffeic acid (an inhibitor of 5-LOX) and celecoxib (an inhibitor on COX-2) were used in combined treatment with ATRA. The results clearly confirmed that the differentiating effects of ATRA shouldbe enhanced via its combined administration with caffeic acid or celecoxib. An increased expression of the genes that encoded the proteins participating in induced differentiation and cytoskeleton remodeling was detected in both cell lines in a concentration-dependent manner. This effect was also observed for the CDKN1A gene encoding the p21 protein, which is an important regulator of the cell cycle, and for the genes encoding proteins that are associated with proteasome activity.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Cell International
ISSN
1475-2867
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
June
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
"nestránkováno"
UT code for WoS article
000338146500001
EID of the result in the Scopus database
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