Novel rapid in vitro cytotoxicity test on mammalian cells based on an electrochemical measuring method
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00079358" target="_blank" >RIV/00216224:14310/14:00079358 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs10800-014-0707-x" target="_blank" >http://link.springer.com/article/10.1007%2Fs10800-014-0707-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10800-014-0707-x" target="_blank" >10.1007/s10800-014-0707-x</a>
Alternative languages
Result language
angličtina
Original language name
Novel rapid in vitro cytotoxicity test on mammalian cells based on an electrochemical measuring method
Original language description
The proliferation of pharmaceuticals and chemicals and the increasing manufacture of medical goods have made an assessment of their potential toxicological risks to man and the environment indispensable. Hence, a wide range of tests has been developed inorder to generate data on the harmful effects of chemicals and pharmaceuticals on organisms. Initially, toxicological data were commonly collected from tests involving animals; however, on account of ethical objections, they are gradually being replacedby in vitro cytotoxicity tests. In this work, a new in vitro screening method for the determination of cytotoxicity, based on a novel electrochemical bioactivity sensor system, was implemented. The evaluation was based on current-time curves of a potentiostatic measurement proportional to the reduction of mediator molecules by mammalian cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LO1214" target="_blank" >LO1214: Research Centre for Toxic Compounds in the Environment</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF APPLIED ELECTROCHEMISTRY
ISSN
0021-891X
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
8
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
935-943
UT code for WoS article
000339723500005
EID of the result in the Scopus database
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