Health safety of parabens evaluated by selected in vitro methods
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F23%3A00014151" target="_blank" >RIV/75010330:_____/23:00014151 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/23:73621528
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0273230022001945?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0273230022001945?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.yrtph.2022.105307" target="_blank" >10.1016/j.yrtph.2022.105307</a>
Alternative languages
Result language
angličtina
Original language name
Health safety of parabens evaluated by selected in vitro methods
Original language description
Seven selected parabens (4 allowed, 3 banned in cosmetics) were tested in order to confirm and expand historical data on their toxicological properties and safety. The aim was to apply novel in vitro methods, which have been sufficiently technically and scientifically validated for the purposes of toxicological testing of chemicals. The study included several toxicological endpoints such as skin/eye irritation, skin sensitization, endocrine disruption and genotoxicity. The battery of selected methods comprised regulatory accepted EpiDermTM skin model (OECD TG 439); EpiOcularTM corneal model (OECD TG 492) and scientifically valid test method HET-CAM (DBALM Protocol No. 47); in chemico test DPRA (OECD TG 442C); in vitro test LuSens (OECD TG 442D) and in vitro test h-CLAT (OECD TG 442E); Ames MPFTM (Xenometrix) and XenoScreen YES/YAS (Xenometrix). Overall, none of the 4 allowed parabens exhibited skin/eye irritation or genotoxicity. However, all allowed parabens in cosmetics were predicted as samples with potentially sensitizing properties in the LuSens and h-CLAT test methods, but not confirmed by DPRA. Endocrine disruption was recorded only at high concentrations, whereas methyl paraben and ethyl paraben exhibited the lowest activity. This study confirmed the safety of use of the allowed parabens in the highest recommended concentrations in cosmetics or pharmaceuticals.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
<a href="/en/project/EF16_019%2F000860" target="_blank" >EF16_019/000860: International competitiveness of NIPH in research, development and education in alternative toxicological methods.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Regulatory Toxicology and Pharmacology
ISSN
0273-2300
e-ISSN
1096-0295
Volume of the periodical
137
Issue of the periodical within the volume
January
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
105307
UT code for WoS article
000897679400005
EID of the result in the Scopus database
2-s2.0-85144589363