Evaluation of toxicity profiles of rare earth elements salts (lanthanides)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F21%3A00013405" target="_blank" >RIV/75010330:_____/21:00013405 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/21:73603841
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1002072119308646?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1002072119308646?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jre.2020.02.011" target="_blank" >10.1016/j.jre.2020.02.011</a>
Alternative languages
Result language
angličtina
Original language name
Evaluation of toxicity profiles of rare earth elements salts (lanthanides)
Original language description
The presented study aims to extend the knowledge of toxicological profile of rare earth elements salts (REEs). The basal toxicity test performed comprised assessment of cytotoxicity (3T3 Balb/c Neutral Red Uptake Test) that allows for calculation of LD50 (rats) on the basis of the concentration which leads to a 50% reduction in cell growth (IC50). Environmental toxicity was addressed by the Tubifex tubifex (T.t.) express test. The in vitro skin irritation (OECD TG 439) and skin corrosion tests (OECD TG 431) utilizing the 3D in vitro reconstructed human epidermal model EpiDerm (MatTek IVSL, SK) were used for assessment of skin irritation and corrosion potential hazard of REEs. Mutagenic effects were determined using the bacterial reverse mutation assay (Ames Test) on 5 Salmonella typhimurium strains with and without metabolic activation (OECD TG 471). Endocrine disruption was evaluated by means of a yeast based assay YES/YAS (Xenometrix, CH). Skin sensitization was assessed using the LuSens assay, based on a genetically modified human keratinocyte cell line (OECD TG 442D). The tested REEs have no potential of mutagenicity or skin sensitization, exhibit very weak endocrine disruption potential and only exceptional local irritation/corrosion effects for thulium (III) chloride anhydrous, but have acute and chronic toxic effects on the aquatic environment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
<a href="/en/project/EF16_019%2F000860" target="_blank" >EF16_019/000860: International competitiveness of NIPH in research, development and education in alternative toxicological methods.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Rare Earths
ISSN
1002-0721
e-ISSN
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Volume of the periodical
39
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
225-232
UT code for WoS article
000617764700016
EID of the result in the Scopus database
2-s2.0-85083004328