Toxicological testing of a photoactive phthalocyanine-based antimicrobial substance
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F28778758%3A_____%2F20%3AN0000020" target="_blank" >RIV/28778758:_____/20:N0000020 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/20:73603845 RIV/75010330:_____/20:00013021
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0273230020301112" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0273230020301112</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.yrtph.2020.104685" target="_blank" >10.1016/j.yrtph.2020.104685</a>
Alternative languages
Result language
angličtina
Original language name
Toxicological testing of a photoactive phthalocyanine-based antimicrobial substance
Original language description
The aim of the study was toxicological testing of an innovative and efficient antimicrobial agent based on photoactive phthalocyanine (Pc) derivative. A promising Aluminium phthalocyanine (AlPc) with efficient and stable antimicrobial effects was subjected to a battery of toxicological tests to avoid local and systemic toxicity hazard. In compliance with the current European legislation restricting the use of experimental animals, the methods comprised exclusively in vitro procedures based on cellular and tissue models of human origin or mimicking human tissues. The battery of toxicological tests to identify local toxicity included skin corrosion/irritation, eye irritation, and phototoxicity. The basic systemic toxicity tests included acute toxicity, skin sensitization, genotoxicity, and endocrine disruption. The results showed that AlPc induced skin and eye irritation, exhibited borderline sensitization potential and mutagenic potential in one test strain of the Ames test, which was not confirmed in the chromosome aberration test. The AlPc was found to be phototoxic. The results from the cytotoxicity test designed for acute oral toxicity estimation were not conclusive, the acute toxicity potential has to be determined by conventional tests in vivo. Regarding endocrine disruption, no agonistic activity of the AlPc on human estrogen receptor α, nor human androgen receptor was observed. The skin penetration/absorption test revealed that the AlPc has not penetrated into the dermis and receptor fluid, confirming no risk of systemic exposure via the bloodstream.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Regulatory Toxicology and Pharmacology
ISSN
0273-2300
e-ISSN
1096-0295
Volume of the periodical
115
Issue of the periodical within the volume
August 2020
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
104685
UT code for WoS article
000551993000004
EID of the result in the Scopus database
2-s2.0-85085569887