The safety assessment of cosmetic perfumes by using in chemico and in vitro methods in combination with GC-MS/MS analysis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F23%3A00014247" target="_blank" >RIV/75010330:_____/23:00014247 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/23:43925838 RIV/61989592:15110/23:73620667

Result on the web

<a href="https://journals.sagepub.com/doi/10.1177/02611929231184635" target="_blank" >https://journals.sagepub.com/doi/10.1177/02611929231184635</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/02611929231184635" target="_blank" >10.1177/02611929231184635</a>

Result language

angličtina

Original language name

The safety assessment of cosmetic perfumes by using in chemico and in vitro methods in combination with GC-MS/MS analysis

Original language description

Animal testing has been prohibited for the safety assessment of cosmetic ingredients or finished products. Thus, alternative non-animal methods, followed by confirmatory clinical studies on human volunteers, should be used as the sole legally acceptable approach within the EU. The safety assessment of cosmetic products requires the involvement of multiple scientific disciplines, including analytical chemistry and biomedicine, as well as in chemico, in vitro and in silico toxicology. Recent data suggest that fragrance components may exert multiple adverse biological effects, e.g. cytotoxicity, skin sensitisation, (photo)genotoxicity, mutagenicity, reprotoxicity and endocrine disruption. Therefore, a pilot study was conducted with selected samples of fragrance-based products, such as deodorant, eau de toilette and eau de parfum, with the aim of integrating results from a number of alternative non-animal methods suitable for the detection of the following toxicological endpoints: cytotoxicity (with 3T3 Balb/c fibroblasts); skin sensitisation potential (in chemico method, DPRA); skin sensitisation potential (LuSens in vitro method, based on human keratinocytes); genotoxicity potential (in vitro Comet assay with 3T3 Balb/c cells); and endocrine disruption (in vitro YES/YAS assay). The presence of twenty-four specific known allergens in the products was determined by using GC-MS/MS. The strategies for estimation of the NOAEL of a mixture of allergens, which were proposed by the Scientific Committee on Consumer Products in their 'Opinion on Tea tree oil' document and by the Norwegian Food Safety Authority in their 'Risk Profile of Tea tree oil' report, were used as models for the NOAEL estimation of the mixtures of allergens that were identified in the individual samples tested in this study.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30108 - Toxicology

Project

<a href="/en/project/EF16_019%2F000860" target="_blank" >EF16_019/000860: International competitiveness of NIPH in research, development and education in alternative toxicological methods.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Alternatives to Laboratory Animals: ATLA

ISSN

0261-1929

e-ISSN

2632-3559

Volume of the periodical

51

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

25

Pages from-to

224-248

UT code for WoS article

001034705500004

EID of the result in the Scopus database

2-s2.0-85163020117