Role of CD36 and GPR120 in fatty acid-mediated Ca2+Signaling in human and mouse taste bud cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00086887" target="_blank" >RIV/00216224:14310/14:00086887 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/chemse/bju073" target="_blank" >http://dx.doi.org/10.1093/chemse/bju073</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/chemse/bju073" target="_blank" >10.1093/chemse/bju073</a>

Result language
angličtina
Original language name
Role of CD36 and GPR120 in fatty acid-mediated Ca2+Signaling in human and mouse taste bud cells
Original language description
Oral perception of dietary fat was until recently thought to involve mainly texture and olfactory cues; however, accumulating evidence strongly suggests existence of a taste modality, devoted to the detection of long-chain fatty acids (LCFA). Mice can recognize dietary fat and FA solutions in the oral cavity in the absence of olfactory or textural cues. Hence, it is important to increase our understanding of gustatory detection of dietary fat and its contribution to fat preference. We studied the rolesof the fat taste receptors CD36 and GPR120 and their interactions via Ca2+ signaling in fungiform taste bud cells (TBC). We measured Ca2+ signaling in human TBC, transfected with small interfering RNAs (siRNAs) against mRNAs encoding CD36 and GPR120 (orcontrol siRNAs). We also studied Ca2+signaling in TBC from CD36?/? mice and from wild-type lean and obese mice. Additional studies were conducted with mouse enteroendocrine cell line STC-1 that express GPR120 and stably transfected with h
Czech name
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Czech description
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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