Hotspot Wizard 2.0

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00080424" target="_blank" >RIV/00216224:14310/15:00080424 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26230/15:PR28671

Result on the web

<a href="http://loschmidt.chemi.muni.cz/hotspotwizard2/" target="_blank" >http://loschmidt.chemi.muni.cz/hotspotwizard2/</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Hotspot Wizard 2.0

Original language description

HotSpot Wizard is a web server for automatic identification of hot spots for engineering of substrate specificity, activity or entantioselectivity of enzymes and for annotation of protein structures. HSW 2.0 integrates 3 databases and 18 computational tools, including our in-house tool for analysis of protein tunnels and channels Caver 3.0. In the output, users can explore hot spots based on 4 protein engineering strategies: (i) functional hot spots represented by highly mutable residues located in the active site pocket or access tunnels, (ii) stability hot spots represented by flexible residues, (iii) stability hot spots identified by back-to-consensus approach, and (iv) correlated hot spots represented by pairs of coevolving residues that modulate enzyme activity and selectivity.

Czech name

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Czech description

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Type

R - Software

CEP classification

IN - Informatics

OECD FORD branch

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Project

<a href="/en/project/TA04021380" target="_blank" >TA04021380: Biosensor for monitoring of toxic compounds in the environment</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Internal product ID

3_2015_LL

Technical parameters

Integrated platform for protein engineering.

Economical parameters

zvýšení ročního obratu

Owner IČO

00216224

Owner name

MU