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Computational Analysis of Protein Tunnels and Channels

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00102092" target="_blank" >RIV/00216224:14310/18:00102092 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1007/978-1-4939-7366-8_3" target="_blank" >http://dx.doi.org/10.1007/978-1-4939-7366-8_3</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/978-1-4939-7366-8_3" target="_blank" >10.1007/978-1-4939-7366-8_3</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Computational Analysis of Protein Tunnels and Channels

  • Original language description

    Protein tunnels connecting the functional buried cavities with bulk solvent and protein channels, enabling the transport through biological membranes, represent the structural features that govern the exchange rates of ligands, ions, and water solvent. Tunnels and channels are present in a vast number of known proteins and provide control over their function. Modification of these structural features by protein engineering frequently provides proteins with improved properties. Here we present a detailed computational protocol employing the CAVER software that is applicable for: (1) the analysis of tunnels and channels in protein structures, and (2) the selection of hot-spot residues in tunnels or channels that can be mutagenized for improved activity, specificity, enantioselectivity, or stability.

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

  • OECD FORD branch

    20400 - Chemical engineering

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Protein Engineering. Methods in Molecular Biology

  • ISBN

    9781493973644

  • Number of pages of the result

    18

  • Pages from-to

    25-42

  • Number of pages of the book

    350

  • Publisher name

    Humana Press

  • Place of publication

    New York, NY

  • UT code for WoS chapter