Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00081110" target="_blank" >RIV/00216224:14310/15:00081110 - isvavai.cz</a>
Result on the web
<a href="http://www.icaac.org/" target="_blank" >http://www.icaac.org/</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans
Original language description
Presenter?s Email: peterdstuart@hotmail.com Amoebiasis, the condition that results from infection with Entamoeba histolytica, is a major global health concern. Infection is common in the tropics, including South-East Asia. Infection can also occur in non-human primates and most recently has been observed in wild orangutans (Pongo sp.). Plants from Indonesia were selected to be tested for activity against E. histolytica, based on observations that orangutans were consuming them more when infected with parasitic protozoa. Methanol and Methanol:Tetrahydrofuran crude extracts were obtained from four plants: Achidendron fagifollium, Diospyros sumatra, Piper betle and Shorea sumatrana. Of these D. sumatra and P. betle showed activity against E. histolytica (IC50 <47microg/ml and IC50 <67 mikrog/ml respectively). The results support the use of these plants for dysentery by local people. They also demonstrate for the first time, that orangutans may be directly self-medicating.
Czech name
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Czech description
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Project
<a href="/en/project/GAP505%2F11%2F1163" target="_blank" >GAP505/11/1163: Anti-inflammatory activity of extracts isolated from selected Indonesian plants and their effect on opportunistic parasitoses</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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