Thermodynamic and Kinetic Study of Mono- and Bis-triazamacrocyclic Ligands and their Transition Metal Complexes Mimicking Hydrolytic Enzyme Activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00081671" target="_blank" >RIV/00216224:14310/15:00081671 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Thermodynamic and Kinetic Study of Mono- and Bis-triazamacrocyclic Ligands and their Transition Metal Complexes Mimicking Hydrolytic Enzyme Activity
Original language description
Polyaza-macrocyclic ligands are recently utilized to bind some radioisotopes for application in medicinal chemistry (60?64,67Cu, 66?68Ga, 86,90Y, 111In) [1,2] and the formed metal complexes of high thermodynamic stability and kinetic inertness are required for their use in vivo for medical purposes. Several copper(II) and zinc(II) complexes of bis-polyaza-macrocyclic ligands catalyse some chemical reactions and therefore they can be used as model systems mimicking enzymes activity. In this work, the protonation constants of novel macrocyclic ligands as well as stability constants of their copper(II) and zinc(II) complexes were determined by glass-electrode potentiometry and molecular absorption spectroscopy. The formation of the copper(II) complexes ofboth ligands is accelerated with increased pH. The dissociation of both copper(II) complexes does not differ within experimental error indicating no cooperative effect for binucleating ligand.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Acta of the International Symposia on Metal Complexes ? ISMEC Acta Vol.5 (2015)
ISBN
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ISSN
2239-2459
e-ISSN
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Number of pages
2
Pages from-to
70-71
Publisher name
University of Wroclaw
Place of publication
Wroclaw
Event location
Wroclaw
Event date
Jan 1, 2015
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
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