Electrochemical and Spectral Behavior of MicroRNA (miR-34a-5p)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00083021" target="_blank" >RIV/00216224:14310/15:00083021 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26220/15:PU116447
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Electrochemical and Spectral Behavior of MicroRNA (miR-34a-5p)
Original language description
MicroRNAs are a family of small noncoding RNAs (21-25 nucleotides), negatively regulating gene expresion at the post-transcriptional level. Their functions are critical to normal cellular processes such as differentiation and apoptosis. recent studies demonstrated that deregulated miRNA expression contributes to the malignant phenotype and for this reason miRNAs play a key role as both diagnostic markers and therapeutic targets for many different tumor types (colorectal cancer, breast cancer, lung cancer, prostate cancer, etc.). Great attention is devoted to the study of miR-34a-5p related to head and neck cancer and also prostate cancer. This miRNA is a direct transcriptional target of p53 and its overexpression after p53 activation mediates some of the key tumor suppressive effects of p53 via induction of growth arrest, apoptisis or senescence.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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