MicroRNAs and zinc metabolism-related gene expression in prostate cancer cell lines treated with zinc(II) ions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00062001" target="_blank" >RIV/00216224:14110/12:00062001 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/12:00191577 RIV/00216305:26620/12:PU100788 RIV/00216208:11130/12:8134 RIV/62157124:16370/12:43871243 RIV/00064203:_____/12:8134
Result on the web
<a href="http://dx.doi.org/10.3892/ijo.2012.1655" target="_blank" >http://dx.doi.org/10.3892/ijo.2012.1655</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/ijo.2012.1655" target="_blank" >10.3892/ijo.2012.1655</a>
Alternative languages
Result language
angličtina
Original language name
MicroRNAs and zinc metabolism-related gene expression in prostate cancer cell lines treated with zinc(II) ions
Original language description
MicroRNAs (miRNAs) are a large class of single-stranded RNA molecules involved in post-transcriptional gene silencing. miRNAs not only regulate various developmental and physiological processes but also are involved in cancer development. Additionally, they can be considered as biomarkers of some pathological processes. The aim of this study was to determine the expression levels of selected miRNA and zinc(II)-related genes (ZIP-1, BAX, MT2A and MT1A) in the non-tumor PNT1A prostate cell line in comparison with the prostate cancer cell lines 22Rv1, PC-3 and LNCaP after zinc(II) treatment. Using bioinformatic approaches we selected miRNAs with putative binding sites in the 3 UTR regions in Metallothionein 1A and 2A as miRNA 23a, 141, 224, 296-3p, 320, 375 and 376. We observed significantly higher expression of miRNA 23a in all tumor lines compared to non-tumor PNT1A (13,6-fold in 22Rv1, 7,3-fold in PC-3, 8,3-fold in LNCaP).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Oncology
ISSN
1019-6439
e-ISSN
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Volume of the periodical
41
Issue of the periodical within the volume
6
Country of publishing house
GR - GREECE
Number of pages
8
Pages from-to
2237-2244
UT code for WoS article
000311587900039
EID of the result in the Scopus database
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