Detection of selected miRNAs in prostate carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F12%3A00198409" target="_blank" >RIV/62156489:43210/12:00198409 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Detection of selected miRNAs in prostate carcinoma

Original language description

MicroRNAs (miRNAs) are small, phylogenetically conserved, noncoding RNAs that are estimated to regulate at least 30% of all protein encoding genes. Mature miRNAs are involved in post-transcriptional gene silencing. They arise from intergenic or intragenic (both exonic and intronic) genomic regions that are transcribed as long primary transcripts. In recent years, miRNAs have received attention as potential cancer diagnostic markers and therapeutic targets [1]. Deregulated miRNAs expressions were reported in various human cancers including prostate cancer. MiRNAs not only regulate various developmental and physiologic processes but also are involved in cancer development and can play roles as important biomarkers. The aim of this study was to determinate the expression levels of selected miRNA in the non-tumour PNT1A line in comparison with tumour lines 22Rv1, PC-3, and LNCaP. We used the TaqMan Gene Expression Assays and quantitative RT-PCR. We observed significantly higher (p<0.01) ex

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/GAP301%2F10%2F0356" target="_blank" >GAP301/10/0356: Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Medicine

ISSN

1107-3756

e-ISSN

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Volume of the periodical

30

Issue of the periodical within the volume

1

Country of publishing house

GR - GREECE

Number of pages

1

Pages from-to

46

UT code for WoS article

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EID of the result in the Scopus database

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