Coordination compounds in cancer: Past, present and perspectives

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00084756" target="_blank" >RIV/00216224:14310/15:00084756 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.jab.2015.03.003" target="_blank" >http://dx.doi.org/10.1016/j.jab.2015.03.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jab.2015.03.003" target="_blank" >10.1016/j.jab.2015.03.003</a>

Result language

angličtina

Original language name

Coordination compounds in cancer: Past, present and perspectives

Original language description

Metal-based coordination compounds have been used throughout the history of human medicine to treat various diseases, including cancer. Since the discovery of cisplatin in 1965, a great number of metal coordination complexes, such as platinum, ruthenium,gold or copper have been designed, synthesized and tested in order to develop clinically effective and safe drugs. Currently, many reviews cover applications of cytostatic metal complexes pointing out the most promising examples of platinum- and non-platinum-based compounds in preclinical and clinical trials. However, recent comprehensive reviews covering chemical and biological aspects of metal-based coordination compounds in cancer therapy are still rare. In this review we wish to provide an overviewof the coordination chemistry of current and novel cytostatic compounds, including an outline of their design and rationale of synthesis, and summarize bio-chemical reactivity and physicochemical properties of candidate metal complexes.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/EE2.3.20.0185" target="_blank" >EE2.3.20.0185: Centre for analysis and modeling of tissues and organs</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of applied biomedicine

ISSN

1214-021X

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

25

Pages from-to

79-103

UT code for WoS article

000354949400002

EID of the result in the Scopus database

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