Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00086654" target="_blank" >RIV/00216224:14310/15:00086654 - isvavai.cz</a>
Alternative codes found
RIV/67985939:_____/15:00448049
Result on the web
<a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124454#abstract0" target="_blank" >http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124454#abstract0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0124454" target="_blank" >10.1371/journal.pone.0124454</a>
Alternative languages
Result language
angličtina
Original language name
Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model
Original language description
Dysregulation of gap junctional intercellular communication (GJIC) has been associated with different pathologies, including cancer; however, molecular mechanisms regulating GJIC are not fully understood. Mitogen Activated Protein Kinase (MAPK)-dependentmechanisms of GJIC-dysregulation have been well-established, recent discoveries have implicated phosphatidylcholine-specific phospholipase C (PC-PLC) in the regulation of GJIC. What is not known is how prevalent these two signaling mechanisms are in toxicant/toxin-induced dysregulation of GJIC, and do toxicants work through either signaling mechanisms or both. Different chemical toxicants were used to assess whether they dysregulate GJIC via MEK or PC-PLC, or both Mek and PC-PLC, or through other signaling pathways, using a pluripotent rat liver epithelial oval-cell line, WB-F344.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LH12034" target="_blank" >LH12034: Novel in vitro approach for identification of chemopreventive effects and mechanisms of phytochemicals.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLOS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
"nestránkováno"
UT code for WoS article
000355319400005
EID of the result in the Scopus database
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