Structure-dependent effects of phthalates on intercellular and intracellular communication in liver oval cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985939%3A_____%2F20%3A00533869" target="_blank" >RIV/67985939:_____/20:00533869 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.3390/ijms21176069" target="_blank" >https://doi.org/10.3390/ijms21176069</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms21176069" target="_blank" >10.3390/ijms21176069</a>
Alternative languages
Result language
angličtina
Original language name
Structure-dependent effects of phthalates on intercellular and intracellular communication in liver oval cells
Original language description
This study with 20 different phthalates identified their structurally dependent effects on inhibition of gap junctional intercellular communication and activation of MAPK-Erk1/2 signaling in rat oval cells. The phthalates with a medium-length side chain (3–6 C) were the most potent dysregulators of GJIC and activators of MAPK-Erk1/2. The effects occurred rapidly, suggesting the activation of non-genomic (non-transcriptional) mechanisms directly by the parental compounds. Short-chain phthalates (1–2 C) did not dysregulate GJIC even after longer exposures and did not activate MAPK-Erk1/2. Longer chain (≥7 C) phthalates, such as DEHP or DINP, moderately activated MAPK-Erk1/2, but inhibited GJIC only after prolonged exposures (>12 h), suggesting that GJIC dysregulation occurs via genomic mechanisms, or (bio)transformation. Overall, medium-chain phthalates rapidly affected the key tissue homeostatic mechanisms in the liver oval cell population via non-genomic pathways, which might contribute to the development of chronic liver toxicity and diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
17
Country of publishing house
CH - SWITZERLAND
Number of pages
21
Pages from-to
1-21
UT code for WoS article
000569736100001
EID of the result in the Scopus database
2-s2.0-85089924980