All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

One point mutation can overturn sugar-binding specificity of lectin RS-IIL from plant pathogen Ralstonia solanacearum

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00087734" target="_blank" >RIV/00216224:14310/15:00087734 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    One point mutation can overturn sugar-binding specificity of lectin RS-IIL from plant pathogen Ralstonia solanacearum

  • Original language description

    A soil bacterium Ralstonia solanacearum is an aggressive phytopathogen which causes severe wilts of many economically important crops in tropical and subtropical regions. This pathogen produces two lectins: RSL and RS-IIL. Lectins are sugar-binding proteins different from sugar-specific antibodies or enzymes. They often play an important role in host-pathogen recognition and interactions. Lectin RS-IIL belongs to a so-called “PA-IIL family”, which includes also lectins PA-IIL (from P. aeruginosa), CV-IIL (from C. violaceum), BC2L-A and BC2L-C (from B. cenocepacia). These lectins are orthologs with significant sequential and structural similarities. Although they bind saccharides with similar stereochemistry, they differ in preferences towards these saccharides. This fact is caused by differences in three amino acids which are arranged in the so-called “specificity binding loop”. Adam et al. prepared three point mutants of the PA-IIL lectin to investigate the fine specificity.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů