Influence of targeted amino acid substitution on specificity and affinity of lectins from pathogenic bacteria

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00057922" target="_blank" >RIV/00216224:14310/12:00057922 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Influence of targeted amino acid substitution on specificity and affinity of lectins from pathogenic bacteria
Original language description
Pseudomonas aeruginosa, Chromobacterium violaceum, Burkholderia cenocepacia and Ralstonia solanacearum are saprophytic bacteria found in various environments, including soil, water and vegetation. The first three bacteria occasionally become aggressive opportunistic animal and human pathogens which attack mainly immunocompromised patients, e.g. patients suffering from cystic fibrosis. The fourth bacterium is economically important plant pathogen. All these bacteria produce lectins. Lectins are proteinswhich are capable of binding diverse carbohydrates with varying specificity. This fact is very important especially in host-pathogen interactions, where lectins help pathogen in adhesion to sugar moieties presented on host cells. Foregoing bacteria produce lectins belonging to a so-called ?PA-IIL family?, namely PA-IIL (P. aeruginosa), CV-IIL (C. violaceum), BC2L-A (B. cenocepacia) and RS-IIL (R. solanacearum). These lectins are orthologues with significant sequential and structural simi
Czech name
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Czech description
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Project
<a href="/en/project/GPP207%2F11%2FP185" target="_blank" >GPP207/11/P185: Preparation of lectins with high specificity and affinity</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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