Analysis of Serum Levels of Cytokines, Chemokines, Growth Factors, and Monoamine Neurotransmitters in Patients With Tick-borne Encephalitis: Identification of Novel Inflammatory Markers With Implications for Pathogenesis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00112262" target="_blank" >RIV/00216224:14310/15:00112262 - isvavai.cz</a>

Alternative codes found

RIV/60077344:_____/15:00451281 RIV/00027162:_____/15:#0001296 RIV/60076658:12310/15:43888819

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.24140" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.24140</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jmv.24140" target="_blank" >10.1002/jmv.24140</a>

Result language

angličtina

Original language name

Analysis of Serum Levels of Cytokines, Chemokines, Growth Factors, and Monoamine Neurotransmitters in Patients With Tick-borne Encephalitis: Identification of Novel Inflammatory Markers With Implications for Pathogenesis

Original language description

Tick-borne encephalitis (TBE) is a leading human neuroinfection in Europe and northeastern Asia. However, the pathophysiology of TBE is not understood completely. This study sought to determine the specific serum mediators that are associated with acute TBE. The levels of 30 cytokines, chemokines, and growth factors were measured in serum samples from 87 patients with clinically and serologically confirmed acute TBE and from 32 control subjects using the Cytokine Human Magnetic 30-Plex Panel for the Luminex platform. Serum levels of the monoamine neurotransmitters serotonin, dopamine, and noradrenaline were measured via enzyme-linked immunosorbent assay. TBE virus infection elicited increased levels of the pro-inflammatory cytokines interleukin (IL)-6, IL-8, and IL-12. TBE patients had higher IL-12:IL-4 and IL-12:IL-10 ratios than control patients, reflecting the global pro-inflammatory cytokine balance. Serum levels of the monoamine neurotransmitters serotonin, dopamine, and noradrenaline were significantly lower in TBE patients than in the control group. Most interestingly, increased levels of hepatocyte growth factor and vascular endothelial growth factor were observed in TBE patients; these proteins may be novel and mechanistically important inflammatory biomarkers of TBE. J. Med. Virol. 87:885-892, 2015.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10607 - Virology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF MEDICAL VIROLOGY

ISSN

0146-6615

e-ISSN

1096-9071

Volume of the periodical

87

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

885-892

UT code for WoS article

000351465000020

EID of the result in the Scopus database

2-s2.0-84925122220