RADIOMETRIC DETERMINATION OF THYROTOXIC EFFECTS OF SOME XENOBIOTICS

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00116081" target="_blank" >RIV/00216224:14310/15:00116081 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/15:00472832

Result on the web

<a href="https://www.rad-conference.org/pdf/Proceedings%20RAD%202015.pdf" target="_blank" >https://www.rad-conference.org/pdf/Proceedings%20RAD%202015.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

RADIOMETRIC DETERMINATION OF THYROTOXIC EFFECTS OF SOME XENOBIOTICS

Original language description

Recently, we have shown in the isolated rat thyroids marked effects of excessive exogenous bromide and perchlorate ions on the activity of thyroid peroxidase (TPO), the key enzyme in thyroid hormones (TH) metabolism. Here, we studied in more details, with the aid of several radioanalytical methods, effects of an enhanced bromide and/or perchlorate intake on various aspects of iodine metabolism and, consequently, on TH metabolism in the rat. Goitrogenic and thyrotoxic effects of excessive bromide and perchlorate ions were followed in adult male rats, maintained on diets with various iodine content, ensuring either sufficient iodine supply or mild to severe iodine deficiency. In rats administered with these xenobiotics we measured a consistent increase in relative weight of the thyroids with increasing time and concentration of applied bromide, and a sharp reduction of the 24-h uptake of [I-131]-iodide by their thyroids. In these animals, we also determined a steady decline in serum total thyroxine concentration. At the molecular level, we found, unexpectedly, that the influence of exogenous bromide on the TPO enzyme activity in the rat thyroids was not simply inhibitory. It was more complex, biphasic with regard to the extent of bromide intake in the animals. With the use of several radioanalytical methods, including adapted radiometric determination of TPO enzyme activity, we therefore confirmed and quantified the presumed thyrotoxic effects of xenobiotics bromide and perchlorate ions.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

20305 - Nuclear related engineering; (nuclear physics to be 1.3);

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

RAD 2015: THE THIRD INTERNATIONAL CONFERENCE ON RADIATION AND APPLICATIONS IN VARIOUS FIELDS OF RESEARCH

ISBN

9788680300016

ISSN

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e-ISSN

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Number of pages

4

Pages from-to

463-466

Publisher name

RAD ASSOC

Place of publication

Serbia

Event location

Budva, MONTENEGRO

Event date

Jun 8, 2015

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000387979700096