WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with G alpha(12/13)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00088209" target="_blank" >RIV/00216224:14310/16:00088209 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1124/mol.116.104919" target="_blank" >http://dx.doi.org/10.1124/mol.116.104919</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1124/mol.116.104919" target="_blank" >10.1124/mol.116.104919</a>

Result language
angličtina
Original language name
WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with G alpha(12/13)
Original language description
Frizzleds (FZDs) are unconventional G protein-coupled receptors that belong to the class Frizzled. They are bound and activated by the Wingless/Int-1 lipoglycoprotein (WNT) family of secreted lipoglycoproteins. To date, mechanisms of signal initiation and FZD-G protein coupling remain poorly understood. Previously, we showed that FZD(6) assembles withG alpha(i1)/G alpha(q) (but not withG alpha(s), G alpha(o) and G alpha(12/13)), and that these inactive-state complexes are dissociated by WNTs and regulated by the phosphoprotein Dishevelled (DVL). Here, we investigated the inactive-state assembly of heterotrimeric G proteins with FZD(4), a receptor important in retinal vascular development and frequently mutated in Norrie disease or familial exudative vitreoretinopathy.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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