All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson’s disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00090372" target="_blank" >RIV/00216224:14310/16:00090372 - isvavai.cz</a>

  • Result on the web

    <a href="http://emboj.embopress.org/content/embojnl/early/2016/06/28/embj.201593725.full.pdf" target="_blank" >http://emboj.embopress.org/content/embojnl/early/2016/06/28/embj.201593725.full.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.15252/embj.201593725" target="_blank" >10.15252/embj.201593725</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson’s disease

  • Original language description

    Pre-B-cell leukemia homeobox (PBX) transcription factors are known to regulate organogenesis, but their molecular targets and function in midbrain dopaminergic neurons (mDAn) as well as their role in neurodegenerative diseases are unknown. Here, we show that PBX1 controls a novel transcriptional network required for mDAn specification and survival, which is sufficient to generate mDAn from human stem cells. Mechanistically, PBX1 plays a dual role in transcription by directly repressing or activating genes, such as Onecut2 to inhibit lateral fates during embryogenesis, Pitx3 to promote mDAn development, and Nfe2l1 to protect from oxidative stress. Notably, PBX1 and NFE2L1 levels are severely reduced in dopaminergic neurons of the substantia nigra of Parkinson’s disease (PD) patients and decreased NFE2L1 levels increases damage by oxidative stress in human midbrain cells.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/EE2.3.20.0180" target="_blank" >EE2.3.20.0180: Cooperation between Masaryk University and Karolinska Institutet, Stockholm in the field of biomedicine</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    The EMBO Journal

  • ISSN

    0261-4189

  • e-ISSN

  • Volume of the periodical

    35

  • Issue of the periodical within the volume

    18

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    16

  • Pages from-to

    1963-1978

  • UT code for WoS article

    000384084900003

  • EID of the result in the Scopus database