How to make a midbrain dopaminergic neuron
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00093845" target="_blank" >RIV/00216224:14310/15:00093845 - isvavai.cz</a>
Result on the web
<a href="http://dev.biologists.org/content/142/11/1918.long" target="_blank" >http://dev.biologists.org/content/142/11/1918.long</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1242/dev.097394" target="_blank" >10.1242/dev.097394</a>
Alternative languages
Result language
angličtina
Original language name
How to make a midbrain dopaminergic neuron
Original language description
Midbrain dopaminergic (mDA) neuron development has been an intense area of research during recent years. This is due in part to a growing interest in regenerative medicine and the hope that treatment for diseases affecting mDA neurons, such as Parkinson's disease (PD), might be facilitated by a better understanding of how these neurons are specified, differentiated and maintained in vivo. This knowledge might help to instruct efforts to generate mDA neurons in vitro, which holds promise not only for cell replacement therapy, but also for disease modeling and drug discovery. In this Primer, we will focus on recent developments in understanding the molecular mechanisms that regulate the development of mDA neurons in vivo, and how they have been used to generate human mDA neurons in vitro from pluripotent stem cells or from somatic cells via direct reprogramming. Current challenges and future avenues in the development of a regenerative medicine for PD will be identified and discussed.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/EE2.3.20.0180" target="_blank" >EE2.3.20.0180: Cooperation between Masaryk University and Karolinska Institutet, Stockholm in the field of biomedicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Development
ISSN
0950-1991
e-ISSN
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Volume of the periodical
142
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
19
Pages from-to
1918-1936
UT code for WoS article
000355209700003
EID of the result in the Scopus database
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