From cellular to chemical approach for acute neural and alternative options for age-induced functional diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F15%3A00508213" target="_blank" >RIV/86652036:_____/15:00508213 - isvavai.cz</a>
Result on the web
<a href="https://www.wjgnet.com/1948-0210/full/v7/i8/1109.htm" target="_blank" >https://www.wjgnet.com/1948-0210/full/v7/i8/1109.htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4252/wjsc.v7.i8.1109" target="_blank" >10.4252/wjsc.v7.i8.1109</a>
Alternative languages
Result language
angličtina
Original language name
From cellular to chemical approach for acute neural and alternative options for age-induced functional diseases
Original language description
Endogenous stem cell niche (SCN) accompanying vessels contains immune system components which in vivo determine differentiation of multi potent stem cells toward proper cell types in given tissue. Combinations of sex steroids may represent novel chemical approach for neuronal areas of regenerative medicine, since they cause transformation of vascular smooth muscle stem cells into differentiating neuronal cells. Circulating sex steroids are present during pregnancy and can be utilized where needed, when various embryonic/fetal tissues develop from their stem cells. Utilization of induced regeneration of tissues (regenerative medicine) is expected being more effective in sudden failures of younger individuals carrying intact SCN, as compared to established chronic disorders caused by SCN alteration. An essential component of SCN are monocyte-derived cells exhibiting tissue-specific stop effect (SE) preventing, for instance, an aging of neuronal cells. Its alteration causes that implantation of neuronal stem cells will also result in their differentiation toward aging cells. When we repair the SE by supply of circulating mononuclear cells from young healthy individuals, we may be able to provide novel regenerative treatments of age-induced neural diseases by sex steroid combinations. Questions regarding some age-induced body alterations are also addressed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
World Journal of Stem Cells
ISSN
1948-0210
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1109-1117
UT code for WoS article
000211114800003
EID of the result in the Scopus database
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