Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00094238" target="_blank" >RIV/00216224:14310/16:00094238 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s12080-016-0300-5" target="_blank" >http://dx.doi.org/10.1007/s12080-016-0300-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12080-016-0300-5" target="_blank" >10.1007/s12080-016-0300-5</a>

Result language

angličtina

Original language name

Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis

Original language description

Despite enormous success of mass immunization programs in reducing incidence of infectious diseases, vaccine-escape strains have emerged perhaps as a consequence of strong selection pressures exerted on parasites by vaccines. Pertussis presents a well-documented example. As a childhood infection, it exhibits age-specific transmission biased to children. Assuming different transmission rates between children and adults, I study, by means of an age-structured epidemic model, evolutionary dynamics of parasite virulence in a vaccinated population. I find that the age-structure does not affect the evolutionary dynamics of parasite virulence. Also, based on empirical data reporting antigenic divergence with vaccine strains and mutations in virulence-associated genes in pertussis populations, I allow for parallel occurrence of mutations in parasite virulence and associated immune evasion.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EH - Ecology - communities

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Theoretical Ecology

ISSN

1874-1738

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

4

Country of publishing house

DE - GERMANY

Number of pages

12

Pages from-to

431-442

UT code for WoS article

000388954400005

EID of the result in the Scopus database

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